The Genetics Podcast
EP 147: From research to delivering precision medicine in the clinic with Scott Weiss, Professor of Medicine at Harvard University
Episode notes
0:00 Intro to The Genetics Podcast
01:00 Welcome to Scott
01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD)
04:56 How and why Scott decided to transition into genetics
06:30 The advances in our understanding of the genetics of asthma and COPD over the past 20 years
10:00 What Scott has learned about translating genomics discoveries into clinical practice and some of the biggest challenges for implementation
13:23 Tackling the reimbursement system in US healthcare and proving the value of preventive, genomics-based care
18:19 Driving down the cost of genomics initiatives such as newborn sequencing to provide high-value impact to patients
19:45 The long-term journey of taking large-scale, longitudinal multi-omic profiling from a research context into healthcare systems
24:10 Creating health-system-associated biobanks at an effective scale and what’s required to achieve that
29:42 Where Scott believes reimbursed predictive omics will first be applied
32:10 Emerging fields in research and personalized medicine that will be key areas of development and discovery in the coming years
36:53 Large-scale prospective biobanks versus a federated approach which piggybacks on existing data collection
39:45 Scott’s current research focus
42:40 What Scott likes to do in his free time outside of academia
43:41 Closing remarks